Abstract Influenza A viruses (IAVs) of subtype H9N2 have reached an endemic stage in poultry farms in the Middle East and Asia.As a result, human infections with avian H9N2 viruses BULLETS have been increasingly reported.In 2017, an H9N2 virus was isolated for the first time from Egyptian fruit bats (Rousettus aegyptiacus).Phylogenetic analyses rev
Purification and characterization of the Lassa virus transmembrane domain
Lassa virus (LASV) is the most prevalent arenavirus afflicting humans and has high potential to become a threat to global public health.The transmembrane domain (TM) of the LASV glycoprotein complex forms critical interactions with the LASV stable signal peptide that are important for the maturation and fusion activity of the virus.A further study
Human-specific protein isoforms produced by novel splice sites in the human genome after the human-chimpanzee divergence
Abstract Background Evolution of splice sites Door Hinge Shim is a well-known phenomenon that results in transcript diversity during human evolution.Many novel splice sites are derived from repetitive elements and may not contribute to protein products.Here, we analyzed annotated human protein-coding exons and identified human-specific splice sites
A review of the use of propensity score diagnostics in papers published in high-ranking medical journals
Abstract Background Propensity scores are widely used to deal with confounding bias in medical research.An incorrectly specified propensity score model may lead to residual confounding bias; therefore it is essential to use diagnostics to assess propensity scores in a propensity score analysis.The current use of propensity BULLETS score diagnostics